Feb 1, 2025

Feb 1, 2025

Feb 1, 2025

Efficacy of Standardized Extract of Bacopa monnieri (Bacognize) on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial

Efficacy of Standardized Extract of Bacopa monnieri (Bacognize) on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial

Efficacy of Standardized Extract of Bacopa monnieri (Bacognize) on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial

Bacopa monnieri, or Brahmi, is an Ayurvedic herb praised for memory support. In this double-blind, placebo-controlled trial, 60 second-year medical students received either 150 mg standardized Bacopa extract or placebo twice daily for six weeks. Participants completed baseline cognitive tests and repeated them after treatment. Those taking Bacopa improved in working-memory and logical-memory tasks, while the placebo group showed no such gains. Blood tests revealed a rise in serum calcium and slight improvements in lipid profiles that remained within normal ranges. The findings suggest that Bacopa supplementation may boost cognitive performance even in individuals with high baseline abilities.

Bacopa monnieri, or Brahmi, is an Ayurvedic herb praised for memory support. In this double-blind, placebo-controlled trial, 60 second-year medical students received either 150 mg standardized Bacopa extract or placebo twice daily for six weeks. Participants completed baseline cognitive tests and repeated them after treatment. Those taking Bacopa improved in working-memory and logical-memory tasks, while the placebo group showed no such gains. Blood tests revealed a rise in serum calcium and slight improvements in lipid profiles that remained within normal ranges. The findings suggest that Bacopa supplementation may boost cognitive performance even in individuals with high baseline abilities.

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Summary of

Efficacy of Standardized Extract of Bacopa monnieri (Bacognize) on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial

By

Navneet Kumar

Navneet Kumar

, et al.

, et al.

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Purpose: Evaluate whether standardized Bacopa monnieri extract improves memory in medical students after six weeks of use.

Methods: In this randomized, double-blind, placebo-controlled trial, 60 second-year medical students aged 19–22 were assigned to receive 150 mg Bacopa extract or placebo twice daily for six weeks. Baseline and post-treatment assessments included digit span and logical memory tests and serum biomarkers.

Results: Two students dropped out; final analyses showed that Bacopa significantly improved digit span backwards and logical memory scores compared with placebo. Serum calcium increased within normal limits, and the Bacopa group’s cholesterol decreased and HDL increased, though lipid changes were not significant versus placebo.

Conclusion: Six weeks of 300 mg daily Bacopa extract enhanced certain memory components even among high-performing individuals. The authors recommend longer studies to assess lasting effects and to explore the role of calcium and neurotransmitter systems.

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