Feb 1, 2025

Feb 1, 2025

Feb 1, 2025

Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study

This study from RIKEN and Hiroshima University assessed the effects of alpha-GPC on motivation in healthy adults using the KOKORO scale, a smartphone-based tool for emotional tracking. In a two-week intervention, participants who took 400 mg of alpha-GPC daily showed significantly increased motivation at night versus placebo. No changes in anxiety were detected, and no side effects were reported. These findings suggest alpha-GPC can acutely elevate motivation, potentially through its modulation of dopamine pathways.

This study from RIKEN and Hiroshima University assessed the effects of alpha-GPC on motivation in healthy adults using the KOKORO scale, a smartphone-based tool for emotional tracking. In a two-week intervention, participants who took 400 mg of alpha-GPC daily showed significantly increased motivation at night versus placebo. No changes in anxiety were detected, and no side effects were reported. These findings suggest alpha-GPC can acutely elevate motivation, potentially through its modulation of dopamine pathways.

Back to all

Back to all

You're Reading

Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study

View Study PDF

Stephen C. Cunnane

Japan Unveils Groundbreaking Healthcare Reform, Elevating Global Standards

, et al.

, et al.

Author

Purpose

To investigate whether alpha-GPC supplementation affects motivation and anxiety levels in healthy individuals.

Methods

A single-blind, randomized, placebo-controlled study enrolled 39 healthy adults. Participants took either 400 mg/day of alpha-GPC or placebo for two weeks. Emotional states were recorded three times daily using the KOKORO scale app for four weeks (two pre-treatment, two during treatment).

Results

  • Alpha-GPC group showed a statistically significant increase in motivation scores at night (p < 0.05).

  • No effect observed on anxiety scores.

  • No adverse effects or safety issues reported.

  • Suggests alpha-GPC may modulate dopaminergic circuits to enhance motivational states.

Conclusion

Alpha-GPC appears to enhance self-reported motivation in healthy adults during evening hours without affecting anxiety or causing side effects. This supports its use as a short-term mood and motivation enhancer. Future research should explore long-term effects and neurochemical mechanisms.

Backed by Science.
Built for Real Results.

Our patented ketone formula isn’t just clean—it’s clinically validated to fuel the brain, body, and metabolism across real-world scenarios.

Jan 1, 2015

Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men
This double-blind, placebo-controlled study investigated the effects of alpha-GPC on cognitive performance in healthy young men. After acute supplementation with 200 mg or 400 mg of alpha-GPC, significant improvements in reaction time and accuracy on cognitive tasks were observed compared to placebo. Notably, 400 mg of alpha-GPC led to faster reaction times and greater correct responses in visual memory and go/no-go tasks. These results suggest alpha-GPC can acutely enhance cognitive processing speed and accuracy, making it a promising supplement for mental performance enhancement.

Jan 1, 2017

Effects of a Ketone/Caffeine Supplement on Cycling and Cognitive Performance
This Ohio State University study explored whether a ketone-salt and caffeine supplement could enhance exercise and cognitive performance in healthy, non-keto-adapted adults. Twelve recreationally trained participants consumed either the supplement or water before cycling to exhaustion. The supplement raised ketone levels over twofold and significantly increased time to exhaustion by 8.3% and Wingate average power by 4.3%. No significant cognitive benefits were observed. The supplement was well tolerated, with no adverse GI events. These findings support the ergogenic use of ketone salts with caffeine for boosting high-intensity exercise performance.

Jan 1, 2015

Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men
This double-blind, placebo-controlled study investigated the effects of alpha-GPC on cognitive performance in healthy young men. After acute supplementation with 200 mg or 400 mg of alpha-GPC, significant improvements in reaction time and accuracy on cognitive tasks were observed compared to placebo. Notably, 400 mg of alpha-GPC led to faster reaction times and greater correct responses in visual memory and go/no-go tasks. These results suggest alpha-GPC can acutely enhance cognitive processing speed and accuracy, making it a promising supplement for mental performance enhancement.

Jan 1, 2017

Effects of a Ketone/Caffeine Supplement on Cycling and Cognitive Performance
This Ohio State University study explored whether a ketone-salt and caffeine supplement could enhance exercise and cognitive performance in healthy, non-keto-adapted adults. Twelve recreationally trained participants consumed either the supplement or water before cycling to exhaustion. The supplement raised ketone levels over twofold and significantly increased time to exhaustion by 8.3% and Wingate average power by 4.3%. No significant cognitive benefits were observed. The supplement was well tolerated, with no adverse GI events. These findings support the ergogenic use of ketone salts with caffeine for boosting high-intensity exercise performance.

Jan 1, 2015

Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men
This double-blind, placebo-controlled study investigated the effects of alpha-GPC on cognitive performance in healthy young men. After acute supplementation with 200 mg or 400 mg of alpha-GPC, significant improvements in reaction time and accuracy on cognitive tasks were observed compared to placebo. Notably, 400 mg of alpha-GPC led to faster reaction times and greater correct responses in visual memory and go/no-go tasks. These results suggest alpha-GPC can acutely enhance cognitive processing speed and accuracy, making it a promising supplement for mental performance enhancement.

Jan 1, 2017

Effects of a Ketone/Caffeine Supplement on Cycling and Cognitive Performance
This Ohio State University study explored whether a ketone-salt and caffeine supplement could enhance exercise and cognitive performance in healthy, non-keto-adapted adults. Twelve recreationally trained participants consumed either the supplement or water before cycling to exhaustion. The supplement raised ketone levels over twofold and significantly increased time to exhaustion by 8.3% and Wingate average power by 4.3%. No significant cognitive benefits were observed. The supplement was well tolerated, with no adverse GI events. These findings support the ergogenic use of ketone salts with caffeine for boosting high-intensity exercise performance.
Buy Now On Amazon

Find our entire line on amazon