Feb 1, 2025

Feb 1, 2025

Feb 1, 2025

Effect of β-Hydroxybutyrate Monoester on Markers of Iron Metabolism in New-Onset Prediabetes: Findings from a Randomised Placebo-Controlled Trial

Effect of β-Hydroxybutyrate Monoester on Markers of Iron Metabolism in New-Onset Prediabetes: Findings from a Randomised Placebo-Controlled Trial

Effect of β-Hydroxybutyrate Monoester on Markers of Iron Metabolism in New-Onset Prediabetes: Findings from a Randomised Placebo-Controlled Trial

This randomized, placebo-controlled human trial investigated the effects of exogenous β-hydroxybutyrate monoester (BHB) on iron metabolism in people with newly diagnosed prediabetes. Over a 4-week period, daily BHB supplementation significantly reduced serum ferritin and increased total antioxidant capacity. These shifts suggest that BHB may help regulate iron homeostasis and lower oxidative stress—factors strongly linked to metabolic dysfunction. This adds a new dimension to ketone-based therapies beyond glucose management.

This randomized, placebo-controlled human trial investigated the effects of exogenous β-hydroxybutyrate monoester (BHB) on iron metabolism in people with newly diagnosed prediabetes. Over a 4-week period, daily BHB supplementation significantly reduced serum ferritin and increased total antioxidant capacity. These shifts suggest that BHB may help regulate iron homeostasis and lower oxidative stress—factors strongly linked to metabolic dysfunction. This adds a new dimension to ketone-based therapies beyond glucose management.

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Summary of

Effect of β-Hydroxybutyrate Monoester on Markers of Iron Metabolism in New-Onset Prediabetes: Findings from a Randomised Placebo-Controlled Trial

By

Xavier Piñeiro-Hermida

Xavier Piñeiro-Hermida

, et al.

, et al.

View Study PDF

Purpose

To determine whether BHB monoester supplementation affects markers of iron metabolism and oxidative stress in individuals with new-onset prediabetes.

Methods

In this double-blind, placebo-controlled trial, 18 prediabetic adults were randomized to receive either 25g of BHB monoester or placebo daily for 4 weeks. Blood samples were analyzed for iron metabolism markers (ferritin, hepcidin) and antioxidant status.

Results

The BHB group showed a significant reduction in serum ferritin (a marker of iron stores and inflammation) and an increase in total antioxidant capacity. No significant changes were observed in serum hepcidin or C-reactive protein. These results suggest that BHB may modulate iron regulation independently of traditional inflammatory markers.

Conclusion

Daily BHB monoester intake can improve iron-related biomarkers and enhance antioxidant defenses in individuals with prediabetes, supporting its role in metabolic health and inflammation reduction.

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Aug 1, 2019

Improvement of cognitive functions by oral intake of Hericium erinaceus
Billed as a medicinal mushroom for centuries, lion’s mane (Hericium erinaceus) is now being studied for its brain‑boosting effects. In this double‑blind, placebo‑controlled trial, 34 adults over 50 were randomized to take powdered H. erinaceus capsules or placebo for 12 weeks; 31 completed the study. Cognitive function was tested at the start, halfway, and end using the Mini Mental State Examination, Benton visual retention, and paired‑associate learning tests. Those who consumed the mushroom saw significant improvement and prevented decline in Mini Mental State scores compared with placebo. No serious side effects were reported, and researchers attribute benefits to neurotrophic compounds in the mushroom.

Jan 1, 2021

Effects of a Ketone/Caffeine Supplement on Cycling and Cognitive Performance
This Ohio State University study explored whether a ketone-salt and caffeine supplement could enhance exercise and cognitive performance in healthy, non-keto-adapted adults. Twelve recreationally trained participants consumed either the supplement or water before cycling to exhaustion. The supplement raised ketone levels over twofold and significantly increased time to exhaustion by 8.3% and Wingate average power by 4.3%. No significant cognitive benefits were observed. The supplement was well tolerated, with no adverse GI events. These findings support the ergogenic use of ketone salts with caffeine for boosting high-intensity exercise performance.

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Improvement of cognitive functions by oral intake of Hericium erinaceus
Billed as a medicinal mushroom for centuries, lion’s mane (Hericium erinaceus) is now being studied for its brain‑boosting effects. In this double‑blind, placebo‑controlled trial, 34 adults over 50 were randomized to take powdered H. erinaceus capsules or placebo for 12 weeks; 31 completed the study. Cognitive function was tested at the start, halfway, and end using the Mini Mental State Examination, Benton visual retention, and paired‑associate learning tests. Those who consumed the mushroom saw significant improvement and prevented decline in Mini Mental State scores compared with placebo. No serious side effects were reported, and researchers attribute benefits to neurotrophic compounds in the mushroom.
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If you want to restore your metabolic health, defeat that midday slump or achieve your personal best, Tecton Ketones is launching a range of specifically formulated products to help reach your goals.