Feb 1, 2025

Feb 1, 2025

Feb 1, 2025

A New Way to Produce Hyperketonemia: Use of Ketone Ester in a Case of Alzheimer’s Disease

A New Way to Produce Hyperketonemia: Use of Ketone Ester in a Case of Alzheimer’s Disease

A New Way to Produce Hyperketonemia: Use of Ketone Ester in a Case of Alzheimer’s Disease

This case study demonstrates the potential of ketone monoester (KME) supplementation to support cognitive function in advanced Alzheimer’s disease. A 63-year-old man with a long-standing diagnosis of AD showed marked improvements in mood, memory, daily function, and self-care when given oral KME over 20 months. Elevated plasma BHB levels (3–7 mM) closely tracked with behavioral and cognitive gains. Unlike ketogenic diets or MCTs, KME induced therapeutic hyperketonemia without dietary changes, offering a practical and potent approach to brain energy rescue in neurodegenerative conditions.

This case study demonstrates the potential of ketone monoester (KME) supplementation to support cognitive function in advanced Alzheimer’s disease. A 63-year-old man with a long-standing diagnosis of AD showed marked improvements in mood, memory, daily function, and self-care when given oral KME over 20 months. Elevated plasma BHB levels (3–7 mM) closely tracked with behavioral and cognitive gains. Unlike ketogenic diets or MCTs, KME induced therapeutic hyperketonemia without dietary changes, offering a practical and potent approach to brain energy rescue in neurodegenerative conditions.

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Summary of

A New Way to Produce Hyperketonemia: Use of Ketone Ester in a Case of Alzheimer’s Disease

By

Mary T. Newport

Mary T. Newport

, et al.

, et al.

View Study PDF

Purpose

To test whether prolonged use of a ketone monoester supplement could safely elevate plasma ketones and improve cognitive and daily function in a patient with Alzheimer’s disease.

Methods

A 63-year-old male with advanced Alzheimer’s was given oral ketone monoester (KME) over a 20-month period, while continuing his usual diet. Plasma BHB levels and cognitive/behavioral changes were monitored. Prior to KME, he had received medium-chain triglycerides (MCTs) with some improvement, but later regressed during a drug trial.

Results

KME induced plasma BHB levels of 3–7 mM, significantly higher than those achieved with MCTs. Noticeable improvements in self-care, mood, memory, and daily activities were reported within days of initiating KME and sustained throughout the treatment period. The patient regained independence in dressing, hygiene, and household tasks. Lipid markers also improved, with reductions in total and LDL cholesterol.

Conclusion

Ketone monoester safely induced robust hyperketonemia and was associated with significant functional and cognitive improvements in an Alzheimer’s patient. This suggests a promising, diet-independent strategy to overcome brain energy deficits characteristic of AD. Larger studies are needed to confirm these findings.

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Effects of a Ketone/Caffeine Supplement on Cycling and Cognitive Performance
This Ohio State University study explored whether a ketone-salt and caffeine supplement could enhance exercise and cognitive performance in healthy, non-keto-adapted adults. Twelve recreationally trained participants consumed either the supplement or water before cycling to exhaustion. The supplement raised ketone levels over twofold and significantly increased time to exhaustion by 8.3% and Wingate average power by 4.3%. No significant cognitive benefits were observed. The supplement was well tolerated, with no adverse GI events. These findings support the ergogenic use of ketone salts with caffeine for boosting high-intensity exercise performance.

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Improvement of cognitive functions by oral intake of Hericium erinaceus
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Jan 1, 2021

Effects of a Ketone/Caffeine Supplement on Cycling and Cognitive Performance
This Ohio State University study explored whether a ketone-salt and caffeine supplement could enhance exercise and cognitive performance in healthy, non-keto-adapted adults. Twelve recreationally trained participants consumed either the supplement or water before cycling to exhaustion. The supplement raised ketone levels over twofold and significantly increased time to exhaustion by 8.3% and Wingate average power by 4.3%. No significant cognitive benefits were observed. The supplement was well tolerated, with no adverse GI events. These findings support the ergogenic use of ketone salts with caffeine for boosting high-intensity exercise performance.

Aug 1, 2019

Improvement of cognitive functions by oral intake of Hericium erinaceus
Billed as a medicinal mushroom for centuries, lion’s mane (Hericium erinaceus) is now being studied for its brain‑boosting effects. In this double‑blind, placebo‑controlled trial, 34 adults over 50 were randomized to take powdered H. erinaceus capsules or placebo for 12 weeks; 31 completed the study. Cognitive function was tested at the start, halfway, and end using the Mini Mental State Examination, Benton visual retention, and paired‑associate learning tests. Those who consumed the mushroom saw significant improvement and prevented decline in Mini Mental State scores compared with placebo. No serious side effects were reported, and researchers attribute benefits to neurotrophic compounds in the mushroom.

Jan 1, 2021

Effects of a Ketone/Caffeine Supplement on Cycling and Cognitive Performance
This Ohio State University study explored whether a ketone-salt and caffeine supplement could enhance exercise and cognitive performance in healthy, non-keto-adapted adults. Twelve recreationally trained participants consumed either the supplement or water before cycling to exhaustion. The supplement raised ketone levels over twofold and significantly increased time to exhaustion by 8.3% and Wingate average power by 4.3%. No significant cognitive benefits were observed. The supplement was well tolerated, with no adverse GI events. These findings support the ergogenic use of ketone salts with caffeine for boosting high-intensity exercise performance.

Aug 1, 2019

Improvement of cognitive functions by oral intake of Hericium erinaceus
Billed as a medicinal mushroom for centuries, lion’s mane (Hericium erinaceus) is now being studied for its brain‑boosting effects. In this double‑blind, placebo‑controlled trial, 34 adults over 50 were randomized to take powdered H. erinaceus capsules or placebo for 12 weeks; 31 completed the study. Cognitive function was tested at the start, halfway, and end using the Mini Mental State Examination, Benton visual retention, and paired‑associate learning tests. Those who consumed the mushroom saw significant improvement and prevented decline in Mini Mental State scores compared with placebo. No serious side effects were reported, and researchers attribute benefits to neurotrophic compounds in the mushroom.
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